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目的探讨急性动脉粥样硬化性脑梗死(ACI)患者血清中性粒细胞明胶酶相关载脂蛋白(NGAL)水平及临床意义。方法收集56例临床诊断为ACI患者作为实验组(ACI组),44例年龄、性别相匹配的健康体检者作为对照组,检测并比较其血清NGAL浓度及其他脑血管病危险因素。结果ACI组血清NGAL水平明显高于对照组(P<0.001),血清NGAL水平与体质量(r=0.25,P<0.05)、空腹胰岛素(r=0.39,P<0.05)以及胰岛素抵抗指数(IR)(r=0.36,P<0.05)正相关,而与高密度脂蛋白胆固醇(r=-0.32,P=0.023)负相关(校正性别及体质量指数后)。多元回归分析提示,NGAL水平与高密度脂蛋白胆固醇和IR独立相关(R2=0.193);Logistic回归分析提示,收缩压、IR和NGAL是ACI的独立影响因子。结论ACI患者血清NGAL水平显著升高,并且NGAL水平与ACI独立相关,检测血清NGAL水平有助于评估ACI风险。
Objective To investigate the serum level of neutrophil gelatinase-associated apolipoprotein (NGAL) in patients with acute atherosclerotic cerebral infarction (ACI) and its clinical significance. Methods Fifty-six ACI patients with ACI were randomly divided into experimental group (ACI group) and 44 age and sex matched healthy subjects as control group. Serum NGAL concentration and other risk factors of cerebrovascular disease were detected and compared. Results The levels of serum NGAL in ACI group were significantly higher than those in control group (P <0.001). The level of serum NGAL was positively correlated with body weight (r = 0.25, P <0.05), fasting insulin ) (r = 0.36, P <0.05), but negatively correlated with high density lipoprotein cholesterol (r = -0.32, P = 0.023) after adjusting for gender and body mass index. Multivariate regression analysis revealed that NGAL levels were independently associated with high-density lipoprotein cholesterol and IR (R2 = 0.193). Logistic regression analysis showed that systolic blood pressure, IR and NGAL were independent influencing factors of ACI. Conclusion Serum levels of NGAL are significantly elevated in patients with ACI and NGAL levels are independently associated with ACI. The detection of serum NGAL levels may be helpful in assessing the risk of ACI.