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目的:观察丁咯地尔注射液与甲钴胺注射液联合治疗糖尿病周围神经病(DPN)的疗效与不良反应。方法:将62例DPN患者随机分为2组,在降血糖等治疗基础上,治疗组给予丁咯地尔注射液200mg+0.9%氯化钠注射液250ml,ivd,qd,甲钴胺注射液0.5mg,im,qd,共4周;对照组丹参注射液20ml代替丁咯地尔注射液,其余用药两组相同。疗效评定根据神经传导速度检查和临床体检。自制副反应量表记录不良反应。结果:4周后治疗组总有效率80.64%,对照组总有效率54.84%,两组差异显著(P<0.05),不良反应差异不明显。结论:丁咯地尔注射液联合甲钴胺注射液治疗DPN疗效肯定,能明显改善临床症状和神经传导速度。安全无明显不良反应。
Objective: To observe the curative effect and adverse reactions of buflomedil injection combined with mecobalamin in the treatment of diabetic peripheral neuropathy (DPN). Methods: Sixty-two patients with DPN were randomly divided into two groups. On the basis of hypoglycemic treatment, the patients in the treatment group were given buflomedil 200mg and 0.9% sodium chloride 250ml, ivd, qd, 0.5mg, im, qd, a total of 4 weeks; control group Danshen injection 20ml instead of buflomedil injection, the remaining two groups of the same medication. Efficacy assessment based on nerve conduction velocity and clinical examination. Self-made adverse reactions recorded adverse reactions. Results: After 4 weeks, the total effective rate was 80.64% in the treatment group and 54.84% in the control group, with significant difference between the two groups (P <0.05). The difference in adverse reactions was insignificant. Conclusion: Buflomedil injection combined with methylcobalamin injection in the treatment of DPN affirmed positive, can significantly improve the clinical symptoms and nerve conduction velocity. No obvious adverse reactions.