小儿迟发性维生素K缺乏常导致急性颅内出血。我院近2年共收治13例,现报告如下。1 临床资料1.1 一般资料男8例,女5例。发病年龄:29～40日龄4例,41～60日龄7例,61～90日龄2例。全部病例均为母乳喂养,出生及发育情况良好,家族成员中无出血病史。伴经常腹泻者7例。1.2症状与体征 针刺部位出血不止13例,前囟紧张饱满12例,惊厥11例,拒奶、双眼凝视、面色苍白各9例,发热、呕吐各5例,剧哭3例。全部病例均于起病后半日内入院治疗。实验室检查:Hb60～90g/L3例,91～110g/L5例,>110g/L5例。血小板计数均>100×109/L。凝血时间正常3例,延长10例。凝血酶原时间13例均延长,最长达9分钟。头颅CT:蛛网膜下腔出血9例,左侧顶枕部硬膜下出血3例,两侧颞部小片状出血1例。行腰穿取脑脊液检查6例,均为均匀的血性脑脊液。1.3 治疗及结果 入院后立即予维生素K,10 mg加入10％葡萄 Delayed vitamin K deficiency in children often leads to acute intracranial hemorrhage. Nearly two years my hospital admitted a total of 13 cases, are as follows. 1 Clinical data 1.1 General Information 8 males and 5 females. Age of onset: 29 to 40 days in 4 cases, 41 to 60 days in 7 cases, 61 to 90 days in 2 cases. All cases were breastfeeding, with good birth and development, and no history of bleeding among family members. With frequent diarrhea in 7 cases. 1.2 Symptoms and signs of bleeding at the acupuncture site in more than 13 cases, anterior fontanelle tension in 12 cases, 11 cases of convulsions, refuse to milk, eyes staring, pale in 9 cases, fever, vomiting in 5 cases, crying in 3 cases. All cases were admitted to hospital within half a day after onset. Laboratory tests: Hb60 ~ 90g / L3 cases, 91 ~ 110g / L5 cases,> 110g / L5 cases. Platelet count were> 100 × 109 / L. Coagulation time was normal in 3 cases, prolonged in 10 cases. Prothrombin time in 13 cases were extended up to 9 minutes. Head CT: 9 cases of subarachnoid hemorrhage, left occipital subdural hemorrhage in 3 cases, both sides of the temporal patch of hemorrhage in 1 case. Lumbar lumbar puncture cerebrospinal fluid examination in 6 cases, are uniform bloody cerebrospinal fluid. 1.3 Treatment and results Immediately after admission to vitamin K, 10 mg of 10% grape