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Psoriasis is a chronic skin disease that affects 2％–3％ of the worldwide population. Western medicine is poorly tolerated and ineffective in the treatment of psoriasis. In comparison to conventional methods, traditional Chinese medicine has been proved to be safe and effective in the treatment of psoriasis by a number of high-quality clinical randomized controlled trials. Previous studies have found that mitochondrial dysfunction may play a critical role in the development of psoriasis. Mitochondrial dysfunction can lead to cell damage caused by excessive generation of mitochondrial reactive oxygen species, induce abnormal apoptosis mainly through mitochondria pathway and affect cell proliferation and differentiation by affecting energy supply. More than that, it releases several inflammatory cytokines and activates inflammatory cells and finally affect the development of psoriasis. The active ingredients in herbal medicine will regulate mitochondrial dysfunction. Therefore, the treatment of psoriasis by regulating mitochondrial dysfunction can provide a new idea for the treatment of psoriasis.