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目的 研究自发性细菌性腹膜炎腹水中肠道细菌潜生体的增殖方式 ,探讨肠道细菌潜生体对肠道粘膜的侵袭性。方法 在生物波理论的基础上 ,建立肠道细菌的波动生长模型 ,观察肠道细菌潜生体在不同 p H、温度、湿度、抗生素状态下的生长变化 ;制备肝硬化鼠动物模型观察肠道细菌潜生体对肠道粘膜的损害。结果 经波动培养后 ,可见肠道潜生体在不同条件下呈现多位断裂、生芽增殖、自旋脱落等多种生长方式 ,可定植在肠粘膜并对肠粘膜具有损伤作用。结论 自发性细菌性腹膜炎腹水中肠道细菌潜生体形成率和群集率可显著增高 ;腹水中潜生体具有较强的繁殖能力、运动能力和抗生素耐受能力 ,具有较强的侵袭力和逃逸巨噬细胞吞噬的能力 ;故认为肠道细菌潜生体在自发性细菌性腹膜炎发生发展中有一定的相关性。
Objective To study the proliferative patterns of intestinal bacterial latent organisms in patients with spontaneous bacterial peritonitis and explore the aggressiveness of intestinal bacteria to intestinal mucosa. Methods Based on the biological wave theory, a model of fluctuating growth of intestinal bacteria was established to observe the growth of intestinal bacteria latent growth under different pH, temperature, humidity and antibiotic status. The animal model of liver cirrhosis was established to observe the intestinal bacteria Latent body damage to intestinal mucosa. Results After fluctuating culture, we can see that the gut latent body showed multiple growths under different conditions, such as multiplication of sprouting, sprouting and spalling, which could be colonized in the intestinal mucosa and damaged the intestinal mucosa. Conclusions The rate and clustering rate of intestinal bacteria latent in ascites in patients with spontaneous bacterial peritonitis can be significantly increased. The ascites have a strong ability of reproduction, exercise and antibiotic tolerance, with strong invasiveness and escape giant Phagocytic capacity of the phagocytes; so that intestinal bacteria latent body in the occurrence of spontaneous bacterial peritonitis have a certain relevance.