目的探讨ｎｍ２３和ｃｅｒｂＢ２癌基因蛋白表达与胃癌根治术后再发癌发生的关系．方法采用免疫组化ＳＰ法检测６４例胃癌中ｎｍ２３和ｃｅｒｂＢ２的表达，并结合内镜及随访资料进行分析．结果胃癌ｎｍ２３低表达率及ｃｅｒｂＢ２阳性率在淋巴结转移组及术后３ａ内有再发癌组明显增高，ｎｍ２３低表达率及ｃｅｒｂＢ２阳性率：有淋巴结转移组为６８９％（３１／４５）和４２２％（１９／４５）；无淋巴结转移组为３６８％（７／１９）和１５８％（３／１９）；术后３ａ内再发癌组为８１０％（１７／２１）和５２４％（１１／２１）；术后３ａ以上无再发癌组为４８８％（２１／４３）和２２６％（１１／４３）（Ｐ＜００５）．而且ｎｍ２３低表达与肿瘤浸润程度有关，浸至浆膜及周围脏器组ｎｍ２３低表达率为７８６％（２２／２８）；浸至粘膜及粘膜下组者为４００％（６／１５）（Ｐ＜００５）．结论胃癌ｎｍ２３低表达和ｃｅｒｂＢ２阳性表达者具有较强的浸润、转移能力，且术后易发生再发癌，二者的表达变化对判断胃癌术后再发癌的发生及预后有重要意义 Objective To investigate the relationship between nm23 and cerbB2 oncogene protein expression and recurrence of cancer after radical resection of gastric cancer. Methods Immunohistochemical SP method was used to detect the expression of nm23 and cerbB2 in 64 cases of gastric cancer. The results were analyzed with endoscopy and follow-up data. Results The low expression rate of nm23 and the positive rate of cerbB2 in gastric cancer were significantly increased in the lymph node metastasis group and recurrent cancer group within 3 years after operation. The low expression rate of nm23 and cerbB2 positive rate were 68.9% in the group with lymph node metastasis ( 31/45) and 42. 2% (19/45); 36.8% (7/19) and 15.8% (3/19) of patients without lymph node metastasis; 81 patients with recurrence within 3 years after surgery. 0% (17/21) and 524% (11/21); 48.8% (21/43) and 226% (11/43) of patients without recurrent cancer after 3 years of surgery (P <005). In addition, the low expression of nm23 was related to the degree of tumor infiltration. The nm23 expression rate was 78.6% (22/28) in the submucosa and surrounding organs, and 40.0% in the submucosa and submucosa groups (6/ 15) (P<005). Conclusions The low expression of nm23 and cerbB2 positive expression in gastric cancer patients have strong ability of invasion and metastasis, and it is prone to recurrent cancer after surgery. The expression changes of both are important for judging the occurrence and prognosis of recurrence of gastric cancer.