论文部分内容阅读
本研究对４２例胃癌病例及４３例胃粘膜异型增生病例行Ｒａｓ癌基因Ｐ２１蛋白、抑癌基因Ｐ５３蛋白单克隆抗体免疫组化研究，结果发现胃癌组织中Ｐ２１阳性率为５４．７％，并与癌组织分化程度呈正相关。Ｐ５３蛋白阳性率为４２．８％，与癌组织分化程度呈负相关，说明胃癌组织中Ｐ２１蛋白及Ｐ５３蛋白的表达与其发生发展有重要关系，并与胃癌的生物学行为有关，在异型增生病例中Ｐ２１及Ｐ５３阳性多为重度病例，说明癌基因的激活与抑癌基因的突变在异型增生发生发展及癌变过程中起着重要作用。
In this study, 42 cases of gastric cancer and 43 cases of gastric mucosal dysplasia were studied by immunohistochemistry of monoclonal antibody against Ras oncogene P21 protein and tumor suppressor gene P53. The results showed that the positive rate of P21 in gastric cancer was 54.7%, and It is positively correlated with the degree of differentiation of cancer tissue. The positive rate of P53 protein was 42.8%, which was negatively correlated with the degree of differentiation of the cancer tissue. This indicates that the expression of P21 protein and P53 protein in gastric cancer tissues has an important relationship with the occurrence and development of gastric cancer, and is related to the biological behavior of gastric cancer in cases of dysplasia. Most of the P21 and P53 positive cases were severe cases, indicating that oncogene activation and tumor suppressor gene mutation play an important role in the development and progression of dysplasia.