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目的探讨中药玉米须对2型糖尿病血清可溶性细胞间粘附分子-1(sICAM-1)及可溶性E-选择素(sE-s)的影响。方法2型糖尿病患者61例根据是否合并冠心病及其严重程度分为3个亚组,糖尿病不合并冠心病组20例,糖尿病合并轻度冠心病组23例,糖尿病合并重度冠心病组18例,以及正常对照组32例。酶联免疫吸附法(ELISA)检测slCAM-1及sE-s水平,酶法测定血糖、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)。所有糖尿病患者每日30g玉米须煎汤服用,4周后重新检测slCAM-1及sE-s水平。结果所有糖尿病患者空腹血糖、TG、TC、LDL-C明显增高,HDL-C降低,糖尿病合并冠心病组血清TC、LDL-C较单纯糖尿病升高(P<0.05),糖尿病组及其亚组sICAM-1及sE-s水平增高(P<0.01),其中合并冠心病者较单纯糖尿病增高(P<0.05),经4周中药玉米须干预后糖尿病组及其亚组sICAM-1及sE-s水平均下降(P<0.05),sICAM-1水平与TC及LDL呈正相关。结论中药玉米须煎汤服用可显著降低2型糖尿病增高的血清可溶性细胞间粘附分子水平。
Objective To investigate the effect of traditional Chinese medicine corn on serum soluble intercellular adhesion molecule-1 (sICAM-1) and soluble E-selectin (sE-s) in type 2 diabetes mellitus. Methods Sixty-one patients with type 2 diabetes were divided into three subgroups according to whether they had coronary heart disease and their severity. There were 20 patients with diabetes without coronary heart disease, 23 patients with diabetes with mild coronary heart disease, and 18 patients with diabetes with severe coronary heart disease. , And the normal control group of 32 cases. Enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of slCAM-1 and sE-s, and enzymatic determination of blood glucose, triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipids Protein cholesterol (LDL-C). All diabetics took 30g corn decoction every day and retested slCAM-1 and sE-s levels after 4 weeks. Results Fasting blood glucose, TG, TC and LDL-C were significantly increased in all diabetic patients, HDL-C was decreased, serum TC and LDL-C levels in diabetics with coronary heart disease were higher than those in simple diabetes (P<0.05), diabetes group and its subgroups. The levels of sICAM-1 and sE-s were increased (P<0.01), and those with coronary heart disease were higher than those with simple diabetes (P<0.05). After 4 weeks of traditional Chinese medicine, corn was required to intervene after diabetes mellitus and its subgroups sICAM-1 and sE- The level of s decreased (P<0.05). The level of sICAM-1 was positively correlated with TC and LDL. Conclusion The use of traditional Chinese medicine corn mustard decoction can significantly reduce the level of serum soluble intercellular adhesion molecule in type 2 diabetes.