论文部分内容阅读
本文研究的目的是探讨短期模拟失重、电离辐射及两者复合因素对大鼠免疫功能的影响及其免疫功能改变的原因.大鼠为实验动物,尾悬吊为模拟失重动物模型~(60)Co为辐射源.结果表明:(1)模拟失重3d后,T淋巴细胞增殖能力、白细胞介素-2(IL-2)和白细胞介素-1(IL-1)的活性无明显改变.模拟失重7d后,T淋巴细胞增殖能力明显降低,IL-2和IL-1的产生仅有下降的趋势.(2)单次 2Gy~(60)Co全身照射3d后,T淋巴细胞增殖能力、IL-2的活性明显降低,7d后都有不同程度的恢复,但仍明显低于正常.IL-1的活性3d时显著增多,7d时IL-1的活性有增高的趋势.(3)电离辐射和模拟失重复合因素作用3d后,T淋巴细胞的增殖能力、IL-2的活性明显降低;复合因素作用7d后,IL-2的产生的变化基本与3d相同.复合因素作用3d后,模拟失重能降低辐射引起的IL-1的升高,7d后IL-1的活性有增高的趋势.(4)各种因素作用后3d,大鼠垂体内的β—内啡肽含量有减少的趋势(辐射组显著降低),7d后β—内啡肽含量明显降低,这一变化趋势同免疫功能的降低基本同步,表明免疫功能降低可能与β—内啡肽的减少有关.
The purpose of this study is to investigate the effects of short-term simulated weightlessness, ionizing radiation and their combined effects on immune function and immune function in rats.Western rats were used as experimental animals, Co as a radiation source.The results showed that: (1) The proliferation of T lymphocytes, the activity of interleukin-2 (IL-2) and interleukin-1 (IL-1) After 7 days of weightlessness, the ability of T lymphocyte proliferation decreased obviously, and the production of IL-2 and IL-1 decreased only. (2) The proliferation of T lymphocytes, IL -2 significantly decreased after 7d, but all of them were still lower than normal after 7d.The activity of IL-1 increased significantly on 3d, and the activity of IL-1 increased on the 7d. (3) Ionizing radiation Compared with the control group, the proliferation of T lymphocytes and the activity of IL-2 were significantly decreased after 3d combined with simulated weightlessness, the change of IL-2 was basically the same as that of 3d after 7 days of combined factors. Can reduce the increase of IL-1 induced by radiation, and the activity of IL-1 tended to increase after 7 days. (4) After 3 days of various factors, The content of β-endorphin in the body tended to decrease (radiation group was significantly reduced), and the content of β-endorphin decreased significantly after 7 days. The change trend was basically synchronous with the decrease of immune function, Reduction of endorphins related.