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癌抑素(canstatin,Cans)是继血管生成抑素(angiostatin)、内皮抑素(endostatin)和肿瘤抑素(tumstatin)之后,新近发现的一种内源性肿瘤血管生成抑制因子,因其具有高效的抗肿瘤血管形成活性而成为肿瘤治疗中的研究热点。本文就Cans的结构、功能、作用机制及在肿瘤治疗中的研究进展作一综述。
Canstatin (Cans) is a recently discovered endogenous tumor angiogenesis inhibitor following angiostatin, endostatin and tumstatin as it has Efficient anti-angiogenic activity has become a hot research topic in the treatment of cancer. This article reviews the structure, function, mechanism of action of Cans and the research progress in the treatment of cancer.