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目的了解北京市散发性戊型肝炎(HEV)的流行病学特征。方法回顾性分析2002年7月-2007年7月首都医科大学附属北京佑安医院就诊的患者17 324例,用酶联免疫吸附试验方法检测血清抗-HEV IgM/IgG的戊型肝炎感染标志物。结果2002-2007年的抗-HEV检测阳性率分别是6.26%,8.83%,11.30%,8.38%,9.36%,各年间比较差异有统计学意义(χ2=56.69,P<0.000);17 324例患者血清抗-HEV共有1 541例阳性(8.94%);抗-HEV阳性患者中男性为1 256例(81.51%),女性285例(18.49%);单纯抗HEV IgM阳性617例(40.04%),单纯抗HEV IgG阳性329例(21.35%),抗-HEV IgM与HEV IgG阳性均为阳性595例(38.61%);戊型肝炎抗体阳性患者中单纯急性戊型肝炎1 067例(69.24%),戊型肝炎病毒重叠感染乙型肝炎患者350例(22.71%),戊型肝炎重叠其他型肝病患者感染124例(8.05%);随着年龄增长抗-HEV阳性率逐渐增加。结论北京市2002-2007年散发性戊型肝炎发病率有波动,并呈明显的年龄特征。
Objective To understand the epidemiological characteristics of sporadic hepatitis E (HEV) in Beijing. Methods A retrospective analysis of 17 324 patients from Beijing You’an Hospital Affiliated to Capital Medical University from July 2002 to July 2007 was performed to detect hepatitis E infection markers of serum anti-HEV IgM / IgG by enzyme-linked immunosorbent assay . Results The positive rates of anti-HEV in 2002-2007 were 6.26%, 8.83%, 11.30%, 8.38% and 9.36%, respectively, with statistical significance in each year (χ2 = 56.69, P <0.000) Among the anti-HEV positive patients, there were 1 256 (81.51%) males and 285 females (18.49%) in the anti-HEV positive patients; 617 (40.04%) were anti-HEV IgM positive patients, , Anti-HEV IgM and HEV IgG positive were all positive in 595 cases (38.61%), pure anti-HEV IgG positive in 329 cases (21.35%); simple hepatitis E antibody in 1067 patients (69.24% , Hepatitis E virus overlap infection in patients with hepatitis B in 350 cases (22.71%), Hepatitis E virus overlap in patients with other types of liver infection in 124 cases (8.05%); With age, anti-HEV positive rate increased gradually. Conclusions The incidence of sporadic EH in Beijing fluctuated from 2002 to 2007 and showed obvious age characteristics.