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NK细胞是一类重要的大颗粒免疫细胞,能杀灭肿瘤细胞和病毒,并参与机体造血的调节。NK细胞受多种因素调节,近来认为一些脑肠肽如VIP、SS等也参与了NK细胞的功能调节,且已积累了不少体内、体外试验证据。作者利用新合成的VIP拮抗剂VIP 4Cl-D-Phe~6-Leu~(17)进一步观察了VIP族激素对人类外周血NK细胞活力的调节作用。
NK cells are a class of important large-granular immune cells that kill tumor cells and viruses and are involved in the regulation of hematopoiesis in the body. NK cells are regulated by a variety of factors. Recently, some brain gut peptides such as VIP and SS are also involved in the regulation of NK cells. Evidence of in vitro and in vivo tests has been accumulated. The authors used the newly synthesized VIP antagonist VIP 4Cl-D-Phe ~ 6-Leu ~ (17) to further observe the role of VIP hormones in the regulation of human peripheral blood NK cell viability.