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影响RNA合成是甲状腺激素在细胞核水平的主要作用。甲状腺激素对许多组织细胞核RNA合成具有普遍性的影响。近年来,随着对甲状腺激素作用机制研究的深入,人们认为,甲状腺激素对RNA合成的某些影响可能与核T_3受体有直接关系,对核RNA合成的普遍性影响可能还涉及转录过程的其它因素。一、核T_3受体与甲状腺激素的作用 Oppenheimer等首次报道了核T_3受体。研究表明,核T_3受体属于染色质酸性非组蛋白,分子量约为5万,象其它酸性非组蛋白一样,核T_3受体也位于两个核小体之间的双螺旋DNA的联接部位,在此部位还有一个作用不明的“相关蛋白”与核T_3受体共存。在含有核T_3受体的染色质中核T_3受体是不可缺少的组份,不同组织细胞核T_3受体的性质是相同的,而且核T_3受体的数量与组织细胞对甲状腺激素的反应敏感性有关。
Effects of RNA synthesis are the major roles of thyroid hormones at the nucleus level. Thyroid hormones have a universal effect on the synthesis of RNA in many tissues of the nucleus. In recent years, with the further study on the mechanism of thyroid hormone, it is thought that some effects of thyroid hormones on RNA synthesis may be directly related to nuclear T 3 receptor, and the general effect on nuclear RNA synthesis may also involve the transcription process Other factors. First, the role of nuclear T_3 receptor and thyroid hormone Oppenheimer et al first reported nuclear T_3 receptor. Studies have shown that the nuclear T_3 receptor belongs to the chromatin acidic non-histone protein, with a molecular weight of about 50,000. Like other acidic non-histone proteins, the nuclear T_3 receptor is also located at the junction of double helix DNA between two nucleosomes , There is an unknown role in this part of the “related protein” and nuclear T_3 receptor coexistence. The nuclear T_3 receptor is an indispensable component in chromatin containing nuclear T_3 receptor. The properties of T_3 receptors in different tissues are the same, and the number of nuclear T_3 receptors is related to the response sensitivity of thyroid hormone to cells .