作者对21例原发性高血压患者,使用长效ACE抑制剂雷米普利(Ramipril),研究对肾血液动力学、肾小球滤过率和心脏功能的作用。A组12例患者,舒张压为95～115mmHg,肾小球滤过率每分钟大于80 ml/1.73m~2,先用安慰剂;B组9例患者,舒张压大于115mmHg,肾小球滤过率每分钟小于80ml/1.73m~2。在安慰剂治疗结束时和用药治疗12周后,检测肾小球滤过率(肌酐)、肾血流(~(131)I-对氨基马尿酸清除率)和M型超声心动图检查。雷米普利的耐受性良好。无副作用。由于减少了总外周阻力,使收缩压和舒张压都 The authors studied the effects on renal hemodynamics, glomerular filtration rate, and cardiac function using a long-acting ACE inhibitor, Ramipril, in 21 patients with essential hypertension. A group of 12 patients, diastolic blood pressure was 95 ~ 115mmHg, glomerular filtration rate greater than 80 ml / 1.73m ~ 2 per minute, first with placebo; B group of 9 patients, diastolic blood pressure greater than 115mmHg, glomerular filtration Over the rate of less than 80ml / 1.73m ~ 2 per minute. Glomerular filtration rate (creatinine), renal blood flow (~ (131) I-parahippimase clearance) and M-mode echocardiography were measured at the end of placebo treatment and after 12 weeks of treatment. Ramipril is well tolerated. No side effects. Systolic and diastolic pressures are both due to reduced total peripheral resistance