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【目的】本文主要探讨铅中毒对儿童甲状腺功能的影响。【方法】入选对象为0~6岁的儿童,血铅采用钨舟原子吸收光谱法测定,并根据血铅的水平<100μg/L,100~200μg/L,200~499μg/L将儿童分为正常血铅组、轻度铅中毒组和中度铅中毒组。对三组对象均采用化学发光免疫技术,分别测其TT3、TT4、FT3、FT4、TSH共5项甲状腺功能指标,并计算出FT4/TSH的比值,将三组甲状腺功能指标和FT4/TSH的比值进行方差分析。【结果】正常血铅组、轻度铅中毒组和中度铅中毒组TT3、TT4、FT3、FT4值差异均无显著性,而三组的TSH值,FT4/TSH比值存在显著性差异。【结论】虽然未达到甲状腺功能低下的程度,但是轻中度铅中毒对儿童甲状腺功能已存在影响;并且随着血中铅浓度的增高,甲状腺功能损害的程度也会加重。
【Objective】 This article mainly discusses the impact of lead poisoning on thyroid function in children. 【Methods】 Children aged 0-6 years were enrolled in this study. Blood lead levels were determined by atomic absorption spectrophotometry. The levels of blood lead <100μg / L, 100-200μg / L and 200-499μg / L were used to divide children into Normal blood lead group, mild lead poisoning group and moderate lead poisoning group. Five groups of thyroid function indexes of TT3, TT4, FT3, FT4 and TSH were measured by chemiluminescence immunoassay, and the ratio of FT4 / TSH was calculated. Thyroid function indexes and FT4 / TSH Variance analysis of variance. 【Results】 There was no significant difference in TT3, TT4, FT3 and FT4 between the normal blood lead group, mild lead poisoning group and moderate lead poisoning group, while the TSH value and FT4 / TSH ratio of the three groups were significantly different. 【Conclusion】 Although the hypothyroidism has not been reached, mild to moderate lead poisoning has had an impact on thyroid function in children. And with the increase of blood lead levels, the degree of thyroid dysfunction will be aggravated.