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目的针对艾滋病患者的病症,探讨艾滋病患者高效抗反转录病毒治疗(HAART)对患者的血清肿瘤坏死因子(TNF-α)、血管紧张素(Ang-Ⅱ)、血清高敏C反应蛋白(hs-CRP)水平的影响。方法通过选取于2016年1—12月期间在孝感市中医医院治疗的40例艾滋病患者作为观察组,同时选取40例检测正常者为对照组。观察组患者施以HAART,对比检测观察组患者在治疗前及治疗后的半年及1年hs-CRP、TNF-α、Ang-Ⅱ水平。使用流式细胞计数法对CD4+T细胞数、CD4+T/CD8进行对比。结果观察组接受HAART前,hsCRP、TNF-α、Ang-Ⅱ水平高于对照组,CD4+T细胞数、CD4+T/CD8低于对照组(均P<0.05);治疗半年和1年后,观察组hs-CRP、TNF-α、Ang-Ⅱ水平较治疗前明显降低,CD4+T细胞数、CD4+T/CD8明显上升(均P<0.05)。结论通过对艾滋病患者施以HAART,能够有效的降低艾滋病患者的血清TNF-α、Ang-Ⅱ、hs-CRP水平,在一定程度上提升患者的自身机体免疫能力。
Objective To investigate the effect of HAART on the serum levels of tumor necrosis factor (TNF-α), angiotensin (Ang-Ⅱ) and serum hs-CRP in patients with AIDS. CRP) levels. Methods Forty AIDS patients treated in Xiaogan City Chinese Medicine Hospital from January to December in 2016 were selected as the observation group and 40 normal controls were selected as the control group. Patients in the observation group were given HAART, and the levels of hs-CRP, TNF-α and Ang-Ⅱ in the observation group were compared before and after treatment for six months and one year. CD4 + T cells and CD4 + T / CD8 were compared using flow cytometry. Results The levels of hsCRP, TNF-α and Ang-Ⅱ in the observation group before HAART were significantly lower than those in the control group. The numbers of CD4 + T cells and CD4 + T / CD8 in the observation group were lower than those in the control group (all P <0.05) The levels of hs-CRP, TNF-α and Ang-Ⅱ in the observation group were significantly lower than those before treatment. The numbers of CD4 + T cells and CD4 + T / CD8 in the observation group were significantly increased (all P <0.05). Conclusions HAART can effectively reduce the level of serum TNF-α, Ang-Ⅱ and hs-CRP in AIDS patients and enhance their own immunity to some extent.