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过去在实验肿瘤研究中多用动物肿瘤模型作为实验材料,但它与人体肿瘤的生物学特性有很大差异,因此研究结果往往不能反映人体肿瘤本质。这种现象在抗癌药物研究中尤为突出,例如对动物肿瘤有效药物,经临床试用结果相关性较差,因此多年来科研工作者一直响往用人体肿瘤模型进行实验肿瘤的研究,这一理想由于裸小鼠(Nude mouse,我国又称无毛、无胸腺小鼠)的发现而成为现实。1966年Flanagan首次报道一种无毛突变型小鼠并定名为裸小鼠(缩写nu/nu)。Pantelouris
In the past, animal tumor models were mostly used as experimental materials in experimental tumor research. However, the biological characteristics of human tumors are very different from those of human tumors. Therefore, the results often do not reflect the nature of human tumors. This phenomenon is particularly prominent in the study of anti-cancer drugs. For example, effective drugs for animal tumors have been poorly corroborated by clinical trial results. For many years, researchers have been eager to study tumors using human tumor models. It has become a reality because of the discovery of nude mice (also known as hairless, athymic mice in our country). In 1966 Flanagan first reported a hairless mutant mouse and was named nude mice (abbr. nu/nu). Pantelouris