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本实验中采用高效液相色谱法(HPLC)测定血浆浓度评价地克珠利固体分散体及地克珠利物理混合物在家兔体内的药动学参数及生物利用度。地克珠利固体分散体和物理混合物的药时曲线下面积(AUC_(0-∝))分别为247.8±18.1μg/h/mL,和145.4±12.6μg/h/mL;C_(max)眦分别为33.72±4.75μg/mL和16.42±3.48μg/mL;t_(1/2)分别为9.53+1.37h和9.23±1.20h。地克珠利固体分散体的口服生物利用度是物理混合物的1.7倍。表明地克珠利固体分散体可应用于制备地克珠利抗球虫制剂。
In this study, HPLC was used to determine the plasma concentration of the drug. The pharmacokinetic parameters and bioavailability of diclazidil solid dispersions and diclazuril physical mixtures in rabbits were evaluated. The area under the curve (AUC_ (0-α)) of the solid dispersion and the physical mixture of diclazuril were 247.8 ± 18.1 μg / h / mL and 145.4 ± 12.6 μg / h / mL, respectively; 33.72 ± 4.75μg / mL and 16.42 ± 3.48μg / mL, respectively; t 1/2 was 9.53 + 1.37h and 9.23 ± 1.20h, respectively. The oral bioavailability of the solid dispersion of diclazuril is 1.7 times that of the physical mixture. This indicates that the solid dispersion of diclazuril can be used to prepare diclofenac anticoccidial preparations.