论文部分内容阅读
我院几年来收治了3例用激素治疗无效的顽固性瘀胆型肝炎,经用秋水仙碱治疗取得了满意疗效,现报告如下。 例1:周某,女,45岁。全身皮肤搔痒、尿黄、皮肤和巩膜黄染1年入院。患者87年10月始不明原因出现乏力、纳差、小便黄似浓茶样。当地经检查诊断为急性黄疸型病毒性肝炎。予以中药治疗月余,乏力、纳差明显好转,渐出现皮肤搔痒,黄疸加深,ALT正常。此后两年内先后用过中药、激素、苯巴比妥治疗,均未见效,1989年5月入本院,查体皮肤巩膜深度黄染,未见肝掌和蜘蛛痣,肝功:ALT>76U/L,SB283.91μmol/L,直接胆红素185.31μmol/L,AKP16.2Uγ-GT342u/L。抗-HBe(+),抗-HBc(+)。肝脏病理显示“肝小叶结构完整,肝细胞轻度浊肿,肝细胞浆内明显瘀胆,微胆栓形成,小叶内多处细胞灶性坏死,并见中性白细胞、淋巴细胞浸润,部分肝窦扩张,枯氏细胞增生,并吞噬胆汁,汇管区
In recent years, our hospital admitted to the 3 cases of refractory stasis with stamina stasis hepatitis, obtained by colchicine treatment with satisfactory results are as follows. Example 1: Zhou, female, 45 years old. Whole body skin itching, urine yellow, skin and sclera yellow dye 1 year admission. Patients 87 years ago unknown causes of fatigue, anorexia, urine yellow like thick tea-like. Locally diagnosed as acute jaundice viral hepatitis. To be more than a month of Chinese medicine treatment, fatigue, anorexia improved significantly, gradually appear itchy skin, jaundice, ALT normal. Herbal medicine and hormones and phenobarbital were used twice in the next two years. All of them were ineffective. In May 1989, she was admitted to our hospital. The sclera of the skin was deeply yellowed with no liver palms and spider nevus. Liver function: ALT> 76U /L, SB283.91μmol / L, direct bilirubin 185.31μmol / L, AKP16.2Uγ-GT342u / L. Anti-HBe (+), anti-HBc (+). Liver pathology showed "complete hepatic lobule structure, mild swelling of hepatocytes, obvious stasis in the cytoplasm of hepatocytes, formation of microthrombosis, multiple focal cell necrosis in the lobes and neutrophils, infiltration of lymphocytes, and partial hepatic Sinus dilation, cell proliferation, engulf bile, portal area