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目的探讨土大黄根提取物对实验性银屑病样模型支配器官形态学变化。方法将咪喹莫特(IMQ)乳膏涂抹BALB/c小背部皮肤形成银屑病样动物模型,观察土大黄根提取物(1,2,4 g/kg)对小鼠支配器官如脑、心、肝脏器指数及其形态学的影响。结果与模型组比较,1,2,4 g/kg组均对小鼠脑、心、肝,脏器指数的影响无统计学差异(P>0.05),同时对脑、心形态学未见明显异常,但可引起肝细胞再生、嗜酸性变性。结论土大黄根提取物对咪喹莫特诱导实验性银屑病小鼠支配器官肝脏组织病理学改变有一定保护和修复作用。
Objective To investigate the morphological changes of rhubarb root extract on experimental psoriasis-like model. Methods IMQ cream was applied to the skin of BALB / c mice to form psoriasis-like animal model. The effects of 1, 4 and 4 g / Heart, liver index and its morphological effects. Results Compared with the model group, there was no significant difference in the indexes of brain, heart, liver and organ among 1, 2 and 4 g / kg groups (P> 0.05), but no obvious morphological changes of brain and heart Abnormal, but can cause liver cell regeneration, eosinophilic degeneration. Conclusion Rhubarb rhizoma root extract may protect and repair the pathological changes in the liver of dominant psoriasis mice induced by imiquimod.