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肝细胞生长因子(hepatocyte growth factor,HGF)是1984年Nakamura从肝部分切除的鼠血浆中分离和部分纯化并命名的〔1〕,是一种分泌型肝素亲和糖蛋白,与肝素及硫酸软骨素有高度亲和力。HGF由间质细胞(如成纤维细胞、巨噬细胞等)产生,与细胞膜上的特异性受体c-Met结合并激活该受?
Hepatocyte growth factor (HGF) was isolated and partially purified from the hepatic partially excised rat plasma in 1984 by Nakamura [1]. It is a secreted heparin-affinity glycoprotein that binds heparin and chondroitin sulfate Has a high affinity. HGF is produced by mesenchymal cells (such as fibroblasts, macrophages, etc.) and binds to and activates the specific receptor c-Met on the cell membrane.