O-糖基化是蛋白质翻译后修饰的主要方式之一。O-糖基化不仅存在于正常的细胞表面,且肿瘤细胞表面常常伴随异常的O-聚糖。Tn抗原、sTn抗原和T抗原是O-聚糖的重要组成部分,在肿瘤表面过度表达,并参与肿瘤转移的过程。本文就O-聚糖参与肿瘤发生发展的分子机制做一简要综述。 O-glycosylation is one of the major ways of post-translational modification of proteins. O-glycosylation is not only present on normal cell surfaces, but often accompanied by abnormal O-glycans on the surface of tumor cells. Tn antigen, sTn antigen and T antigen are important components of O-glycans, which are overexpressed on the tumor surface and involved in tumor metastasis. This article reviews the molecular mechanism of O-glycans involved in tumorigenesis.