乳腺癌易感基因(Breast cancer susceptibility gene,Brca-1)是肿瘤抑制基因家族中的一员,它是乳腺癌特异性抑癌基因,1994年Miki等[1]采用定位克隆方法首次将Brca-1分离出来。Brca-1能防止细胞过快地或失去控制地生长和分化,在调节细胞进程、DNA损伤修复、细胞生长与凋亡及转录活化和抑制等多种生物学途径都发挥重要作用,Korhonen等2003年报道Brca-1基因可促进体外培养的大鼠来源的神经干细胞的增殖。 Breast cancer susceptibility gene (Breca-1) is a member of the tumor suppressor gene family, which is a breast cancer-specific tumor suppressor gene. In 1994, Miki et al [1] 1 separated. Brca-1, which prevents cells from growing and differentiating rapidly or uncontrollably, plays an important role in a variety of biological pathways such as regulation of cellular processes, DNA damage repair, cell growth and apoptosis, and transcriptional activation and repression, Korhonen et al. 2003 The Brca-1 gene was reported to promote the proliferation of rat-derived neural stem cells cultured in vitro.