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目的 :对国产及进口比索洛尔进行降压疗效及谷 /峰比值的比较 ,以判断其降压疗效及副作用。方法 :按照 1993年WH0高血压的诊断标准 ,将门诊入选的高血压患者分为A组 2 0例 (进口组 ) ,B组 2 0例 (国产组 )。服用安慰剂 2周后进行药物治疗 8周 ,治疗前后进行AB、P、及T/P的测定。结果 :治疗后A组血压下降SBP 34mmHg,DBP 2 7mmHg ,B组血压下降SBP 2 3.6mmHg ,DBP 19mmHg ,两组间血压下降无差异性。T/P比值A组平均T/P比值 70 % ,B组药平均T/P比值为 5 7%。结论 :两种比索洛尔均可达到全日的有效降压效果 ,无明显副作用。
OBJECTIVE: To compare the antihypertensive effect and valley / peak ratio of domestic and imported bisoprolol in order to determine its antihypertensive efficacy and side effects. Methods: According to the diagnostic criteria of WH0 hypertension in 1993, 20 outpatients with hypertension were divided into A group (20 cases) and B group (20 cases). After 2 weeks of placebo treatment for 8 weeks, before and after treatment AB, P, and T / P determination. Results After treatment, the blood pressure in group A decreased 34 mmHg and DBP 2 7 mmHg in group A, and decreased in group B by 3.6 mmHg and DBP 19 mmHg respectively. There was no difference in blood pressure between the two groups. The average T / P ratio of T / P ratio group A was 70%, and the average T / P ratio of group B drug was 57%. Conclusion: Both bisoprolol can achieve full-day effective antihypertensive effect with no obvious side effects.