论文部分内容阅读
目的：探讨ＨＣＶ感染与肝癌组织中癌基因ｃ－ｅｒｂＢ－２表达的关系。方法：采用免疫组化ＳＰ法。结果：４６例ＨＣＣ及其３８例癌旁组织中，ＨＣＶＮＳ３抗原的检出率分别为２１．７％和３４．２％，两者间差异不显著（Ｐ＞０．０５）；癌基因ｃ－ｅｒｂＢ－２蛋白的检出率分别为４７．８％和４４．７％，两者间差异不显著（Ｐ＞０．０５）；肝癌组织中癌基因ｃ－ｅｒｂＢ－２蛋白表达的阳性率与该患者的ＨＣＶ感染无关（Ｐ＞０．０５）。结论：ＨＣＶ感染与ｃ－ｅｒｂＢ－２蛋白表达无关，提示ＨＣＶ的致癌可能与ｃ－ｅｒｂＢ－２癌基因的激活无关。
Objective: To investigate the relationship between HCV infection and the expression of oncogene c-erbB-2 in hepatocellular carcinoma. Methods: Immunohistochemical SP method was used. RESULTS: The detection rates of HCV NS3 antigen in 46 cases of HCC and 38 cases of adjacent tissues were 21.7% and 34.2%, respectively. There was no significant difference between the two groups (P>0.05). Oncogene c- The detection rates of erbB-2 protein were 47.8% and 44.7%, respectively. There was no significant difference between them (P>0.05). The positive rate of c-erbB-2 protein expression in hepatocellular carcinoma was similar to that of erbB-2 protein. The patient’s HCV infection was not related (P>0.05). CONCLUSION: HCV infection is not related to the expression of c-erbB-2 protein, suggesting that the oncogenicity of HCV may not be related to the activation of c-erbB-2 oncogene.