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目的探讨三联疗法联合冬虫夏草发酵菌粉治疗幽门螺杆菌(Hp)阳性萎缩性胃炎的临床疗效。方法选取2015年6月—2016年5月于华中科技大学同济医学院附属协和医院消化门诊收治的Hp阳性萎缩性胃炎患者64例,随机将患者分为观察组与对照组,每组28例。对照组予以三联疗法(埃索美拉唑片+阿莫西林胶囊+左氧氟沙星胶囊)治疗,观察组在对照组基础上予以百令片治疗,比较两组患者临床疗效、症状(萎缩、肠上皮化生、非典型增生)疗效、Hp根除率及不良反应发生情况。结果观察组总有效率高于对照组(P<0.05)。观察组患者萎缩、肠上皮化生、非典型增生症状疗效高于对照组(P<0.05)。观察组患者Hp根除率高于对照组,不良反应发生率低于对照组(P<0.05)。结论三联疗法联合冬虫夏草发酵菌粉治疗Hp阳性萎缩性胃炎的临床疗效确切,可有效根除Hp,降低不良反应发生率。
Objective To investigate the clinical efficacy of triple therapy combined with Cordyceps sinensis fermentation powder in the treatment of Helicobacter pylori (Hp) -positive atrophic gastritis. Methods Sixty-four patients with Hp-positive atrophic gastritis treated in the digestive clinic of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology from June 2015 to May 2016 were randomly divided into observation group and control group with 28 cases in each group. The control group was treated with triple therapy (esomeprazole tablets + amoxicillin capsules + levofloxacin capsules). The observation group was treated with Bailing tablets on the basis of the control group. The clinical efficacy, symptoms (atrophy and intestinal metaplasia Health, atypical hyperplasia) efficacy, Hp eradication rate and adverse reactions. Results The total effective rate in observation group was higher than that in control group (P <0.05). The observation group patients with atrophy, intestinal metaplasia, atypical hyperplasia symptoms more effective than the control group (P <0.05). Hp eradication rate in the observation group was higher than that in the control group, and the incidence of adverse reactions was lower than that in the control group (P <0.05). Conclusion The triple therapy combined with Cordyceps sinensis fermentation powder for the treatment of Hp positive atrophic gastritis clinical curative effect is exact, can effectively eradicate Hp, reduce the incidence of adverse reactions.