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目的探讨经阴道彩色多普勒超声(TVCDS)结合血清肿瘤标志物HE4、CA125检测对卵巢癌早期诊断的临床应用价值。方法选取临床拟诊为附件肿块而入院行择期手术的患者151例,根据术后病理诊断结果分为A组(卵巢癌组)48例和B组(卵巢良性病变组)103例。手术前所有患者均接受TVCDS检查以及血清HE4、CA125水平的测定,并与手术治疗后的病理诊断结果作比较分析。结果 A组患者的血清HE4、CA125水平与B组患者比较均大幅度升高;TVCDS参数S/D、PI及RI与B组患者比较均明显降低。TVCDS、HE4、CA125联合对卵巢癌进行诊断时总一致性、敏感性、特异性、阳性预测值、阴性预测值分别为94.70%、93.75%、95.15%、90.00%、97.03%,且高于单独检查时的值。结论 TVCDS结合血清HE4、CA125水平测定有助于卵巢癌临床诊断水平的提高。
Objective To investigate the clinical value of transvaginal color Doppler ultrasound (TVCDS) combined with serum tumor markers HE4 and CA125 in the early diagnosis of ovarian cancer. Methods One hundred and fifteen patients were enrolled in this study. The patients were divided into group A (ovarian cancer) 48 cases and group B (benign ovarian disease 103 cases) according to the postoperative pathological diagnosis. All patients underwent TVCDS and serum levels of HE4 and CA125 before surgery, and were compared with the pathological diagnosis results after surgery. Results The serum levels of HE4 and CA125 in group A were significantly increased compared with those in group B. The TVCDS parameters S / D, PI and RI were significantly lower in group B than in group B. The overall consistency, sensitivity, specificity, positive predictive value and negative predictive value of TVCDS, HE4 and CA125 in the diagnosis of ovarian cancer were 94.70%, 93.75%, 95.15%, 90.00% and 97.03%, respectively, Check the value. Conclusion TVCDS combined with serum levels of HE4 and CA125 are helpful for the clinical diagnosis of ovarian cancer.