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目的 :了解 2型糖尿病高危人群空腹血糖分布规律及其对糖尿病的筛检价值。方法 :对无糖尿病症状的6 80例 2型糖尿病高危人群行 75 g口服葡萄糖耐量试验 ,对其空腹血糖水平分组分析 ,并评价不同水平空腹血糖对糖尿病的筛检价值。结果 :糖尿病、糖耐量低减和糖耐量正常的发生率分别为 19.85 %、2 0 .14%和 6 0 .0 0 % ;空腹血糖均值分别为 ( 6 .30± 0 .93) mm ol/ L、( 5 .2 5± 0 .83 ) mm ol/ L和 ( 4.5 6± 0 .74) mm ol/ L ( P值均 <0 .0 5 ) ;空腹血糖95 %的可信区间分别为 6 .10～ 6 .6 5 m mol/ L ,5 .2 0～ 5 .5 5 m mol/ L和 4.6 1～ 4.88m mol/ L。评价筛检试验显示在糖尿病高危人群中各指标在空腹血糖≥ 6 .0 m mol/ L或≥ 6 .5 mmol/ L时对糖尿病的综合预测价值略优于空腹血糖≥ 7.0 mmol/ L。结论 :在高危人群中筛检糖尿病效能较高 ,空腹血糖仍不失为发现糖尿病的早期简便方法 ,在糖尿病高危人群中空腹血糖仍可以反应糖代谢的变化趋势
Objective: To understand the distribution of fasting blood glucose and the screening value of diabetes in people at risk of type 2 diabetes. Methods: A total of 680 high risk population with type 2 diabetes without diabetes mellitus were enrolled in the 75 g oral glucose tolerance test. Their fasting blood glucose levels were analyzed by grouping, and the screening value of different levels of fasting blood glucose for diabetes mellitus was evaluated. Results: The incidences of diabetes, impaired glucose tolerance and normal glucose tolerance were 19.85%, 20.14% and 60.0%, respectively; mean fasting blood glucose were (6.30 ± 0.93) mm ol / L, (5.52 ± 0.83) mm ol / L and (4.56 ± 0.74) mm ol / L respectively (P values <0.05). The 95% confidence intervals of fasting blood glucose were 6.10-6.65 m mol / L, 5.2-2.5-5.5 m mol / L and 4.6-1-4.88 m mol / L, respectively. Evaluation screening tests showed that the comprehensive predictive value of diabetes mellitus with fasting blood glucose> 6.0 mmol / L or ≥6.5 mmol / L in diabetes mellitus was slightly better than that of fasting blood glucose ≥ 7.0 mmol / L. CONCLUSION: Screening for diabetes is more effective in high-risk population. Fasting blood glucose remains an early and convenient method for detecting diabetes. Fasting plasma glucose may still reflect the changing trend of glucose metabolism in high-risk population of diabetes