Objectives:To retrospectively analyze the clinical results of the treatment of pulmonary multifocal adenocarcinoma presenting as ground glass opacity(GGO)by surgery and thermal ablation.Methods:87 GGO-type pulmonary adenocarcinomas of 48 patients(14 males and 34 females;mean age:59.7 years old ±9.9,range:33-79 years old)had been treated from March 2015 to March 2019.Treatment means included 43 wedge resections,7 segmentectomy,17 lobectomies,and 20 thermal ablations.The indication selected for treatment means,safety,and local tumor progression rate were evaluated.Results:No operation-related death occurred in all patients.42 times of surgery were performed and 67 carcinomas were resected in 42 patients.23 times of single-port Video-assisted thoracoscopic surgery(VATS),8 times of two-port VATS and 11 times of three-port VATS were performed in total.There were 2 cases of air leak(exceeding 1 week),1 case of chylothorax and 1 case of massive pleural effusion.Time duration of surgery was between 60 and 300mins(mean:167mins).Intra-operative blood loss was between 5 and 300 mL(mean:44 mL).Time of chest drainage was between 2 and 23d(mean 4.9d).Chest drainage volume was be-tween 14 and 4633 mL(mean:872 mL).Post-operation LOS(length of stay)was between 3 and 25d(mean:6.2d).15 times of thermal ablation were performed(1 case of air leak)and 20 carcinomas were ablated in 14 patients.The ablation time was between 30 and 120min(mean:43min);post-operation LOS was between 1 and 10d(mean:3.5d).During the mean follow-up period(16 months ± 13)(range:5-60 months),no local tumor progression occurred.Conclusions:Surgery and thermal ablation are safe and effective options for the treatment of pulmonary multifocal GGO-type adenocarcinoma.