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目的:分析0～3岁儿童血清25羟维生素D3〔25-(OH)D3〕水平,为科学合理地补充维生素D制剂提供理论依据。方法:随机抽取2010年3月～2011年10月于该院儿童保健门诊就诊的儿童1 462例,用ELISA法检测血清25-(OH)D3水平。结果:无锡市0～3岁儿童25-(OH)D3的平均水平为(79.92±22.97)nmol/L,男女童之间差异无统计学意义(P>0.05);早产儿25-(OH)D3水平为(69.63±26.9)nmol/L,明显低于非早产儿水平(80.3±22.74)nmol/L,差异有统计学意义(P<0.05);不同季节检测儿童25-(OH)D3水平之间差异有统计学意义(P<0.05),而在相同季节检测的6月龄和12月龄儿童25-(OH)D3水平差异无统计学意义(P>0.05);儿童25-(OH)D3水平出生后随着月龄而渐增加,至5月龄达最高峰,之后渐下降,不同年龄差异有统计学意义(P<0.01)。结论:无锡市0～3岁儿童血清25-(OH)D3水平较为适宜,早产儿25-(OH)D3水平低于非早产儿,0～3岁儿童25-(OH)D3水平自出生后随着月龄增加而增高,至5月龄达最高峰,之后渐下降。
OBJECTIVE: To analyze the serum 25-hydroxyvitamin D3 (25- (OH) D3) in children aged 0-3 years and provide a theoretical basis for the scientific and rational vitamin D preparation. Methods: A total of 1 462 children were selected randomly from March 2010 to October 2011 in the children’s health clinic of the hospital. Serum 25- (OH) D3 levels were measured by ELISA. Results: The average level of 25- (OH) D3 in children aged 0-3 years in Wuxi was (79.92 ± 22.97) nmol / L, there was no significant difference between boys and girls (P> 0.05) D3 level was (69.63 ± 26.9) nmol / L, which was significantly lower than that of non-premature children (80.3 ± 22.74) nmol / L, the difference was statistically significant (P0.05), while there was no significant difference in 25- (OH) D3 between 6-month-old and 12-month-old children tested in the same season (P> 0.05) ) The level of D3 gradually increased with age at birth, reached the peak at 5 months of age, and then decreased gradually with different age groups (P <0.01). Conclusion: The level of 25- (OH) D3 in children aged 0-3 years in Wuxi is more suitable, the level of 25- (OH) D3 in preterm infants is lower than that in non-premature infants, and the level of 25- (OH) D3 in children aged 0-3 years Increased with age, reached the peak at 5 months of age, then gradually decreased.