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目的探讨急性脑梗死(acute cerebral infarction,ACI)患者血小板膜糖蛋白(glycoproteinⅡb/Ⅲa,GPⅡb/Ⅲa)纤维蛋白原受体PAC-1和P选择素(P-Selectin,CD62p)与ACI患者病情严重程度的相关性。方法采用流式细胞仪技术分别检测58例ACI患者急性期(<7 d)外周血PAC-1和CD62p含量,同时采用Barthel指数和NIHSS量表评分法对ACI患者进行神经功能学评分,并选取20名健康人作为对照组进行参考值测定。结果与对照组(0.22±0.13;4.21±1.11)相比,ACI患者PAC-1含量(0.92±0.40)和CD62p含量(7.07±3.07)在急性期(<7 d)显著升高(P<0.05;P<0.05),且与ACI患者病情严重程度成正相关(P<0.05;P<0.01)。结论 PAC-1和CD62p与ACI患者病情严重程度呈正相关。早期检测PAC-1和CD62p水平对于预防ACI发生、评估病情轻重以及判断预后有着重要的意义。
Objective To investigate the clinical significance of PAC-1 and P-selectin (CD62p) and ACI in patients with acute cerebral infarction (ACI) Degree of relevance. Methods Flow cytometry was used to detect the levels of PAC-1 and CD62p in peripheral blood of 58 patients with ACI at acute stage (<7 d). Neurological scores of ACI patients were evaluated by Barthel index and NIHSS scale, respectively. Twenty healthy people were used as control group for reference value determination. Results Compared with control group (0.22 ± 0.13; 4.21 ± 1.11), PAC-1 levels (0.92 ± 0.40) and CD62p contents (7.07 ± 3.07) were significantly increased in ACI patients (< ; P <0.05), and positively correlated with the severity of ACI (P <0.05; P <0.01). Conclusion PAC-1 and CD62p are positively correlated with the severity of ACI. Early detection of PAC-1 and CD62p levels for the prevention of ACI, assess the severity and prognosis of great significance.