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文献已经证实粗制煤焦油(CCT)或其含有的成分在体外有致癌和诱变特性。作者测定5名健康正常成人外用CCT后的血标本,测定CCT的各种成分的吸收情况。 5名健康不吸烟的成人志愿者,试验前一周抽血标本作对照。一周后每名受试者给予2％粗制煤焦油凡士林软膏85g,涂躯干和四肢,每晚一次,8小时后淋浴,连用2天,第2次淋浴后抽血,立即置-15℃冰冻保存。测定时使冰冻的血标本在室温
It has been demonstrated in the literature that crude coal tar (CCT) or its components are carcinogenic and mutagenic in vitro. The authors measured blood samples from 5 healthy adults after external topical CCT and determined the absorption of various components of CCT. Five healthy non-smoker adult volunteers took blood samples one week prior to the test as a control. One week later, each subject was given 2% crude coal tar petrolatum ointment 85g, applied to the trunk and extremities, once per night, 8 hours after the shower, once every 2 days, after the second shower, immediately set at -15 ° C frozen save. Frozen blood samples were taken at room temperature