论文部分内容阅读
miRNA是一类含有22个nt左右的内源性短小非编码RNA,可作用于mRNA使之降解或者抑制翻译来调节靶基因的表达。哺乳动物雷帕霉素靶蛋白(mammals target of rapamycin,mTOR)是一种丝/苏氨酸蛋白激酶,近年来有研究表明mTOR集成了多个信号通路控制着有机体的生长和体内平衡。目前,大量研究表明miRNA能靶向mTOR相关信号通路对肿瘤产生影响。因此,本文主要探讨m TOR相关信号通路与肿瘤的关系,综述miRNA靶向m TOR相关信号通路对肿瘤的影响,旨在为肿瘤的靶向性治疗提供更好的理论依据。
MiRNAs are a class of 22-nt endogenous short, non-coding RNA that acts on mRNAs to degrade or suppress translation to regulate target gene expression. Mammalian mammals target of rapamycin (mTOR) is a silk / threonine protein kinase. In recent years, studies have shown that mTOR integrates multiple signaling pathways to control the growth and homeostasis of the organism. At present, a large number of studies have shown that miRNA can affect the tumor by targeting mTOR-related signaling pathways. Therefore, this article mainly discusses the relationship between mTOR-related signaling pathways and tumors, and reviews the effects of miRNA-targeted mTOR-related signaling pathways on tumors and aims to provide a better theoretical basis for targeted therapy of tumors.