微生物制药设计性实验是提高学生专业技能和培养创新能力的一种重要途径。为提高教学质量,我们在设计性实验教学中开展了基于问题的学习(PBL)教学模式。PBL教学模式的引入显著地提高了学生的学习积极性,锻炼了学生分析和解决问题的能力,增强了沟通和交流能力。本文报道PBL教学模式在微生物制药设计性实验中的实施情况,并对实施过程中出现的一些问题进行分析和探讨。 Microbiological design experiments are an important way to improve students’ professional skills and cultivate their innovative abilities. In order to improve the quality of teaching, we develop a problem-based learning (PBL) teaching model in the design of experimental teaching. The introduction of PBL teaching mode significantly improves students’ enthusiasm for learning, improves their ability to analyze and solve problems, and enhances their communication and communication skills. This paper reports the implementation of PBL teaching mode in the design experiment of microbial pharmacy, and analyzes and discusses some problems that occurred during the implementation.