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目的 探讨脑梗死患者PPARγmRNA表达变化和脑梗死体积的关系。方法 序贯收集2002年7月～2003年1月在湘雅医院神经内科就诊的发病3天以内的符合入选标准的脑梗死患者32例,同时收集相匹配的同期体检者30例作对照。用RT-PCR法测定两组对象空腹周围血淋巴细胞PPARγmRNA表达情况。所有脑梗死患者依据发病后48～72小时CT检查结果,计算脑梗死体积。结果 脑梗死患者和对照组PPARγmRNA表达值分别为0.238±0.05和0.841±0.07,两组比较差异显著;脑梗死患者PPARγmRNA表达和脑梗死体积呈负相关(r=-0.664,P<0.001)。结论 发病3天内脑梗死患者周围血淋巴细胞PPARγmRNA表达下调,并和脑梗死体积呈负相关。
Objective To investigate the relationship between the changes of PPARγmRNA and the volume of cerebral infarction in patients with cerebral infarction. Methods Thirty-two patients with cerebral infarction who met the inclusion criteria within 3 days after onset of neurology in Xiangya Hospital from July 2002 to January 2003 were collected. Meanwhile, 30 matched matched subjects were collected as control. The mRNA expression of PPARγ in peripheral blood lymphocytes of two groups was measured by RT-PCR. All patients with cerebral infarction based on 48 to 72 hours after onset of CT examination results, calculate the volume of cerebral infarction. Results The expression of PPARγmRNA in patients with cerebral infarction and control group were 0.238 ± 0.05 and 0.841 ± 0.07, respectively. There was significant difference between the two groups. The expression of PPARγmRNA in cerebral infarction was negatively correlated with the volume of cerebral infarction (r = -0.664, P <0.001). Conclusion The expression of PPARγmRNA in peripheral blood lymphocytes in patients with cerebral infarction within 3 days after onset is down-regulated and negatively correlated with the volume of cerebral infarction.