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目的 探讨脑缺血模型长爪沙鼠近交系培育过程中血液生理生化指标动态变化.方法 应用Beckman全自动生化分析仪 (CX5) 和日本光电全自动血细胞分析仪 (MEK-7222K) 对近交第11至20代 (F11到F20) 近交系长爪沙鼠17项血液生化和22项血常规指标进行检测.结果 F1120长爪沙鼠的尿酸 (URIC) 、乳酸脱氢酶 (LD) 、肌酸激酶 (CK) 、丙氨酸氨基转移酶 (ALT) 、高密度脂蛋白胆固醇 (HDLD) 、镁 (MG) 、红细胞 (RBC) 、白细胞 (WBC) 、嗜酸性粒细胞 (EOS) 、中性粒细胞 (NEUT) 、单核细胞 (MON) 、嗜碱性粒细胞 (BAS) 、血小板 (PLT) 、血小板压积 (PCT) 、血小板体积分布宽度 (PDW) 、血红蛋白 (HGB) 、平均红细胞血红蛋白量 (MCH) 、红细胞体积分布宽度 (RDW) 呈现上升趋势, 淋巴细胞 (LYM) 、肌酐 (CRE) 、尿素氮 (BUN) 、碱性磷酸酶 (ALP) 、葡萄糖 (GLU) 呈现下降趋势;红细胞压积 (HCT) 、红细胞平均体积 (MCV) 、平均红细胞血红蛋白浓度 (MCHC) 、血小板平均体积 (MPV) 趋势平稳, 多数指标F17后趋于平稳.结论 长爪沙鼠近交培育对其多数血液生理生化指标具有一定的影响.“,”Objective To investigate a dynamic curve of blood biochemical and physiological characteristics in the process of inbreeding ischemia-prone gerbil, and to provide basic data for inbred animal breeding. Methods The 17 blood biochemical and 22 physiological indices of blood samples from inbred 11 th to 20 th generation (F11 to F20) were detectioned by Beckman automatic biochemical analyzer (CX5) and Japanese photoelectric automatic blood cell analyzer (MEK-7222K). Results The results showed that the uricacidcrystal (URIC), lactate dehydrogenase (LD), creatine kinase (CK), alanine aminotransferase (ALT), high density lipoproteins (HDLD), magnesium (MG), red blood cell (RBC), leukocyte (WBC), eosinophil (EOS), neutrophil count (NEUT), monocytes (MON), basophilic granulocyte (BAS), blood platelet (PLT), thrombocytocrit (PCT), platelet distribution width (PDW), hemoglobin (HGB), mean corpuscular hemoglobin (MCH), and red blood cell distribution width (RDW) of F11-20 gerbil were increasing. The lymphocyte (LYM), creatinine (CRE), blood urea nitrogen (BUN), alkaline phosphatase (ALP), glucose (GLU) showed a decreasing trend. The hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), average platelet volume (MPV) value was stable. The majority of indicators tend to be stable after F17. Conclusion The gerbil inbred strain has a certain influence on the most of the blood physiological and biochemical indices.