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实验与临床研究提示前列环素(Prostacyclin. PGI_2)的调节和血栓素A_2生物合成的紊乱在动脉粥样硬化的发病机理上可能起重要作用。且系幼儿缺血性心脏病的先兆及预示以后将发展成缺血性心脏病。作者调查了有动脉粥样硬化家族史儿童的前列腺素(Prostaglandin,PG)和脂质代谢情况。对象和方法:3～14岁匈牙利儿童被分成三组。无心脏病家族史的健康儿童为对照组。测定其104人(男孩45,女孩59)的脂质和43人(男孩19,女孩24)的PG。父母于45岁前患急性心肌梗塞的儿童被分成二组,第一组40人(男孩23,女孩17),家中无其它心脏病史;第二组42人(男孩15,女孩27),其父、母和家庭成员至少一人患有缺血性心
Experimental and clinical studies suggest that the regulation of prostacyclin (PGI_2) and the disorder of thromboxane A_2 biosynthesis may play an important role in the pathogenesis of atherosclerosis. And Department of early childhood ischemic heart disease and predict the future will develop into ischemic heart disease. The authors investigated prostaglandin (PG) and lipid metabolism in children with a family history of atherosclerosis. Subjects and methods: Hungarian children aged 3 to 14 are divided into three groups. Healthy children without family history of heart disease served as control group. The PG of its 104 (male 45, female 59) lipid and 43 (male 19, female 24) were measured. Parents of children with acute myocardial infarction before the age of 45 were divided into two groups, the first group of 40 (boys 23, girls 17), no other heart disease at home; the second group of 42 (boys 15, girls 27) At least one mother and family member has ischemic heart disease