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以光镜、电镜、胶体金探针免疫电镜、组化和免疫组化等方法，观察１６例脾原发性非何杰金淋巴瘤（ＮＨＬ），发现其镜下分布有三种基本类型，即结节型、弥漫型和过渡型。发现属低度恶性的不同组织学类型ＮＨＬ在红髓和白髓有特殊的浸润方式：结节型小裂细胞性，其结节分布于整个脾脏的红髓，大小及分布较一致，未见侵犯红髓，但有独特的侵犯中央动豚周围Ｔ细胞淋巴鞘的形态，且可能与淋巴细胞循环和“归家”机制有关；过渡型小无裂细胞性，主要呈结节状，但红髓可见小片弥漫的瘤细胞浸润，并与结节有移行改变；过渡型Ｂ混合细胞性，结节较少，部分红髓破坏，代之以弥漫分布的瘤细胞。而弥漫型则主要见于恶性程度较高的组织细胞性和大裂细胞性等。此外，还讨论了脾原发性ＮＨＬ的鉴别诊断、诊断标准、大体分型和临床特点等问题。
Using light microscopy, electron microscopy, colloidal gold probe immunoelectron microscopy, histochemistry, and immunohistochemistry, 16 cases of primary splenic non-Hodgkin’s lymphoma (NHL) were observed and found to have three basic types of microscopic distribution. Nodular, diffuse and transitional. It was found that different histological types of low-grade NHL had a special infiltration pattern in the red and white pulp: nodular small crack cells, their nodules were distributed throughout the red pulp of the spleen, and their size and distribution were consistent. Invades the red pulp, but has a unique pattern of invading the T-cell lymphatic sheath around the central moving dolphins, and may be related to lymphocyte circulation and “home” mechanisms; transitional small non-cleaved cells, mainly nodular, but red The myelin shows small tumors with diffuse tumor cell infiltrates and transitions with nodules; transitional B mixed cells with few nodules and partial red pulp destruction and replaced with diffusely distributed tumor cells. The diffuse type is mainly found in the cells with high degree of malignancy, such as histiocytic cells and large fissure cells. In addition, the differential diagnosis, diagnostic criteria, general classification, and clinical features of splenic primary NHL were also discussed.