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目的:分析不同剂量酒精摄入对CHA_2DS_2-VASc低危组男性非瓣膜病心房颤动(房颤)患者并发缺血性卒中风险的影响。方法:对2009-2012年在郑州大学人民医院和郑州大学第一附属医院就诊的男性非瓣膜性房颤患者应用CHA_2DS_2-VASc评分量表评估卒中风险。最终选出CHA_2DS_2-VASc评分0分和1分的患者共1 256例。按照日常饮酒量分为少量组(678例)、中量组(263例)、大量组(315例)。随访48个月,比较3组缺血性卒中发病率的差异。结果:3组发生缺血性卒中的患者分别为10例(1.474%)、4例(1.521%)、14例(4.444%)。少量组和中量组患者比较差异无统计学意义;大量组与少量组和中量组比较,差异均有统计学意义。结论:大量酒精摄入可增加CHA_2DS_2-VASc评分低危组男性非瓣膜病房颤患者缺血性卒中的风险。
Objective: To investigate the effect of different doses of alcohol intake on the risk of ischemic stroke in non-valvular atrial fibrillation (AF) patients with CHA_2DS_2-VASc low risk group. Methods: The risk of stroke was assessed using the CHA_2DS_2-VASc scale in male patients with non-valvular atrial fibrillation who were treated at People’s Hospital of Zhengzhou University and the First Affiliated Hospital of Zhengzhou University from 2009 to 2012. A total of 1 256 patients with CHA_2DS_2-VASc score of 0 and 1 were selected. According to the daily consumption of alcohol into a small group (678 cases), the amount of group (263 cases), a large number of groups (315 cases). The patients were followed up for 48 months. The differences of incidence of ischemic stroke in the three groups were compared. Results: The incidence of ischemic stroke in 3 groups was 10 cases (1.474%), 4 cases (1.521%) and 14 cases (4.444%). There was no significant difference between the small group and the moderate group. There was significant difference between the large group and the small group and the medium dose group. Conclusions: Large alcohol intake increases the risk of ischemic stroke in men with non-valvular atrial fibrillation in the low-risk CHA 2 DS 2 -VASc group.