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目的分析衢州市耐多药肺结核耐药谱与治疗转归,为耐多药肺结核治疗提供依据。方法收集2010年3月—2013年6月耐多药肺结核的资料,对治疗情况进行分析。结果 71例耐多药肺结核中,耐药种数所占比例前3位依次为耐3种药(39.43%)、耐4种药(25.35%)和耐2种药(18.31%)。纳入全球基金结核病项目治疗41例,治疗满6个月25例,6月末痰菌阴转率80.00%;是否耐氧氟沙星是6月末痰检阴转率的影响因素(P<0.05)。结论耐多药肺结核耐3种及以上药物所占比例较高;经规范的化疗方案,坚持规则服药,治疗满6个月者的痰菌阴转率较高。
Objective To analyze the resistant spectrum and treatment outcome of multidrug-resistant pulmonary tuberculosis in Quzhou City and provide evidence for multi-drug resistant tuberculosis treatment. Methods The data of MDR-TB from March 2010 to June 2013 were collected and the treatment situation was analyzed. Results Among the 71 MDR-TB cases, the top three in the proportion of resistance-resistant tuberculosis were resistance to three drugs (39.43%), resistance to four drugs (25.35%) and resistance to two drugs (18.31%). 41 cases were treated in the Global Fund TB Project, 25 cases were treated for 6 months and the rate of sputum negative conversion rate was 80.00% at the end of June. Whether orofloxacin was the influencing factor of sputum test negative conversion rate at the end of June (P <0.05). Conclusions Multidrug-resistant pulmonary tuberculosis is resistant to three or more drugs in a high proportion. With standardized chemotherapy regimens, regular sputum vaginal conversion is high when patients are treated for 6 months.