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目的：观察白大衣高血压血压血脂干预与颈动脉内膜中层厚度(IMT)、血清总胆固醇(TC)、血清高敏c-反应蛋白(hscrp)、血清肾素(renin)关系。方法选择75例经动态血压检测仪检出的白大衣高血压患者随机分为干预组和观察组,并选择同期健康查体者52例作为对照组,干预组加以血脂血压干预,观察组和对照组不加任何干预,测定干预前,干预后3个月,6个月的TC、hsCRP、renin水平以及IMT,对三组数据进行统计学分析。结果白大衣高血压组干预前和对照组相比,TC、hsCRP、renin水平以及IMT有统计学意义(﹤0.05)；干预组干预后的3个月、6个月TC、hsCRP、renin水平以及IMT方面与观察组相比,各项指标明显改善明显改善,差异有统计学意义(﹤0.05)；与对照组相比,干预组干预后的3个月、6个月TC、hsCRP、renin水平以及IMT方面无统计学意义(>0.05)。结论白大衣高血压患者有早期动脉硬化指标,对白大衣高血压及早的血压血脂干预能减少远期心脑血管并发症。“,”Objective To evaluate the ef ect of Carotid Intima-media Thickness, serum hscrp, serum renin, serum TC in patients with White coat hypertension before and after treatment. Methods 75 patients with white coat hypertension were randomly divided into intervention group and observation group, and 52 cases of healthy physical examination as control group,.the Carotid Intima-media Thickness, serum hscrp, serum renin, serum TC of the three groups were detected before and after treatment. Results Compared to control group,the levels of serum TC, hscrp, renin levels and IMT benfore treatment in white coat hypertension group was statistical y significant ( ﹤0.05);and after treatment, compared to observation group, the levels of serum TC, hscrp, renin levels and IMT in intervention group was statistical y significant ( ﹤0.05);Compared to control group, ,the levels of serum TC, hscrp, renin levels and IMT in intervention group after the intervention three months, six months has no statistical significance ( >0.05). Conclusion Patients with white coat hypertension had early arteriosclerosis, and early intervention of blood pressure blood fat can reduce long-term complications of Cardiovascular events.