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本文总结了用 CODP 方案诱导化疗的初治儿童ALL 84例,观察临床中常见的副作用,如骨髓抑制等,对这些毒副作用的临床特点作了较全面的分析。结果表明:骨髓最大抑制期为化疗后的第7~10天,第18~20天开始恢复。诱导化疗后肝肾异常的发生率分别为33.3%及11.9%,前者主要为药物作用所致,在高、低危 ALL 间没有差异,后者则以高危为主。化疗中58.3%有消化道反应,以恶心、呕吐为主。52.8%的患儿合并各种感染性疾病,其中33.3%为粘膜溃疡或炎症,与 HD-MTX 的应用有关。2.4%可在使用 L-ASP 后发生急性坏死性胰腺炎。
This article summarizes the 84 cases of ALL children who were initially treated with chemotherapy induced by CODP regimen and observed the common clinical side effects such as myelosuppression. The clinical features of these toxicities and side effects were analyzed comprehensively. The results showed that the maximal inhibitory period of bone marrow was 7 to 10 days after chemotherapy, and the recovery began on the 18th to 20th days. The incidence of liver and kidney abnormalities after induction chemotherapy were 33.3% and 11.9% respectively. The former was mainly caused by the drug effect, and there was no difference between high and low risk ALL patients. The latter was mainly at high risk. Chemotherapy 58.3% have gastrointestinal reactions, mainly to nausea and vomiting. 52.8% of children with various infectious diseases, of which 33.3% were mucosal ulcers or inflammation, and the application of HD-MTX. 2.4% Acute necrotizing pancreatitis can occur after using L-ASP.