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目的:研究宫颈上皮内瘤变(cervical intraepithelial neoplasia,CIN)的诊治方法。方法:回顾性分析1996年1月~2007年12月1 206例CIN患者的临床资料。结果:1996~2003年CIN患者88例,2004~2007年增至1 118例,1996~2003年CIN发病高峰年龄为36~40岁(22.00%),2004~2007年CIN发病高峰年龄为31~35岁(25.33%)。2004~2007年CINⅠ的平均患病年龄较1996~2003年提前2.7岁,CINⅡ提前2.4岁,CINⅢ提前2.5岁。治疗CINⅢ所采取的术式变化明显,2003年开始行阴式扩大性宫颈切除术,而冷刀锥切术(cold knife conization,CKC)的临床应用呈上升趋势,全子宫切除术从8.0%上升至10.3%。结论:宫颈上皮内瘤变发病数逐年上升且有年轻化趋势,宫颈冷刀锥切术为外科治疗的主要术式。
Objective: To study the diagnosis and treatment of cervical intraepithelial neoplasia (CIN). Methods: The clinical data of 1 206 CIN patients from January 1996 to December 2007 were analyzed retrospectively. Results: From 1996 to 2003, 88 cases of CIN increased from 1,188 cases from 2004 to 2007. The peak age of CIN from 1996 to 2003 was 36 to 40 years old (22.00%), and the peak age of CIN from 2004 to 2007 was 31 ~ 35 years old (25.33%). The mean age of onset of CINⅠ between 2004 and 2007 was 2.7 years earlier than that of 1996 ~ 2003, CINⅡ was 2.4 years old and CINⅢ 2.5 years earlier. The surgical procedure adopted for treatment of CINⅢ changed obviously. In 2003, vaginal enlarging cervical resection was performed. The clinical application of cold knife conization (CKC) was on the rise. The total hysterectomy increased from 8.0% To 10.3%. Conclusions: The incidence of cervical intraepithelial neoplasia has been increasing year by year and tends to be younger. The surgical method of cervical cold knife conization is the main surgical procedure.