转铁蛋白受体是肿瘤细胞表面的一种标志。许多学者相继用同位素标记转铁蛋白(Tf),进行肿瘤阳性显像的探索,均发现肿瘤组织有明显的核素浓集,但与正常组织的反差尚不够大。本实验基于Tf经DNP化修饰后,未改变其与受体的亲和力且体外酶标检测可提高敏感度和特异性,试图用DNP-Tf与~125Ⅰ-抗DNP IgG作肿瘤放大导向的探索。 Transferrin receptors are a hallmark of tumor cell surface. Many scholars have been using the isotope labeling transferrin (Tf) to carry out the exploration of tumor positive imaging. All found that the tumor tissue has obvious nuclide concentration, but the contrast with normal tissue is not yet large enough. In this study, based on the TNP modified by DNP, it did not change its affinity with the receptor and in vitro enzyme labeling can improve the sensitivity and specificity, trying to use DNP-Tf and ~ 125I-anti-DNP IgG for tumor amplification-oriented exploration.