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难治性肾病是指激素治疗无效(激素抵抗型),或激素依赖型或反复发作型,因不能耐受激素的副作用而难以继续用药的原发性肾病综合征。其中,反复发作型是指肾病完全缓解后一年内反复发作4次或半年内发作超过2次以上者。此类病人的治疗是肾内科研究的主要课题之一。近年来,我们在应用激素的同时,采用Ⅳ—CTX治疗成人难治性肾病26例,获良好疗效,报告如下。 1 对象与方法 1.1 对象:1993～1997年7月住院治疗的难治性肾病患者46例,按入院日期(单、双日),随机分为Ⅳ—CTX组(治疗组)和CTX传统治疗组(即对照组)。治疗组26例,男16例,女10例;年龄17～54岁,平均35.5岁;病程6～34月。其中,激素抵抗型
Refractory nephropathy refers to the steroid therapy is not effective (hormone-resistant type), or hormone-dependent or recurrent type, because they can not tolerate the side effects of hormones and difficult to continue treatment of primary nephrotic syndrome. Among them, recurrent type refers to the complete remission of renal disease within one year of repeated episodes of 4 or 6 months within the seizure of more than 2 times. The treatment of such patients is one of the main topics in the study of nephrology. In recent years, we use hormones at the same time, the use of IV-CTX treatment of refractory renal disease in 26 cases, a good effect, the report is as follows. 1 Subjects and Methods 1.1 Subjects: 46 cases of refractory nephropathy hospitalized in hospital from July 1993 to July 1997 were randomly divided into Ⅳ-CTX group (treatment group) and CTX traditional treatment group (Ie control group). The treatment group of 26 patients, 16 males and 10 females; aged 17 to 54 years old, an average of 35.5 years of age; duration of 6 to 34 months. Among them, hormone-resistant type