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多囊卵巢综合征(PCOS)是育龄期妇女常见的内分泌紊乱性疾病,发病率达6%~10%。由于稀发排卵或无排卵,常常伴发不孕的问题。近年来,辅助生殖技术(ART)越来越多地应用于此类患者。研究表明不同类型的PCOS患者,如肥胖、高促黄体生成激素(LH)、高雄激素及胰岛素抵抗(IR),其ART助孕结局均较非PCOS患者差,虽然发生机制各有特点,但不同的病理生理异常相互作用,最终多反映为卵子质量下降,表现为PCOS患者ART治疗的临床妊娠率低、早期自然流产率高。本文就不同类型的PCOS患者的辅助生殖治疗结局以及影响其结局的因素进行论述,并探讨能够改善PCOS患者辅助生殖治疗结局的措施。
Polycystic ovary syndrome (PCOS) is a common endocrine disorders in women of childbearing age, the incidence rate of 6% to 10%. Because of rare or no ovulation ovulation, often associated with infertility problems. In recent years, assisted reproductive technology (ART) is increasingly used in such patients. Studies have shown that different types of PCOS patients, such as obesity, high luteinizing hormone (LH), hyperandrogenism and insulin resistance (IR), their ART assisted pregnancy outcomes were worse than non-PCOS patients, although the mechanism of occurrence of each have different characteristics, but different Of the pathophysiology of abnormal interactions, and ultimately reflect the decline in the quality of the egg, showed PCOS patients ART treatment of clinical pregnancy rate is low, high rate of early spontaneous abortion. This article discusses the different types of patients with PCOS assisted reproductive therapy outcomes and the factors that affect their outcome are discussed, and to explore ways to improve PCOS patients with assisted reproductive treatment outcome measures.