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目的研究利心丸对小鼠缺氧耐受的影响并初步探讨其机理。方法小鼠随机分生理盐水(每天20g/kg)组、心得安(每天0.16g/kg)组、利心丸高剂量(每天5g/kg)和低剂量(每天1g/kg)组,连续给药5天并于末次给药1h后测定小鼠缺氧耐受能力以及血清乙酰胆碱酯酶(T-ChE)和总抗氧化能力(T-AOC)。结果利心丸低剂量组耗氧率和心得安组均较生理盐水组显著降低(P<0.05或0.01);心得安组T-ChE活性较生理盐水组显著增高(P<0.01);心得安组和利心丸高剂量组T-AOC均较生理盐水组显著增高(P均<0.01)。结论利心丸低剂量能提高小鼠抗常压的缺氧耐受能力,可能与提高机体总抗氧化能力有关。
Objective To study the effect of Lixin Pills on hypoxia tolerance in mice and to explore its mechanism. Methods Mice were randomly divided into normal saline (20g/kg daily) group, propranolol (0.16g/kg per day) group, Lixin Pills high dose (5g/kg per day) and low dose (1g/kg per day) groups. The mice were tested for hypoxia tolerance and serum acetylcholinesterase (T-ChE) and total antioxidant capacity (T-AOC) after 5 days of drug administration and 1 h after the last administration. Results The oxygen consumption rate in the low-dose Lixin Pill group and the propranolol group were significantly lower than those in the normal saline group (P<0.05 or 0.01); the T-ChE activity in the propranolol group was significantly higher than that in the normal saline group (P<0.01); Propranolol The T-AOC in the high-dose group and Lixin Pills were significantly higher than those in the normal saline group (P<0.01). Conclusion The low dose of Lixin Pill can improve the anti-anoxia tolerance ability of mice against normal pressure, which may be related to the increase of total antioxidant capacity of the body.