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目的探讨中央角膜厚度(CCT)与Perkins压平眼压的关系,建立CCT、真实眼压与Perkins压平眼压三者关系的数学模型和CCT对Perkins压平眼压的校正公式。方法健康新西兰大耳白兔32只,双眼中1只眼行准分子激光屈光性角膜切削术(PRK),另1只眼测得的数据对行PRK眼得出的数据进行验证。采用随机数字表法随机取1只眼,采用PRK,人为改变兔眼的CCT,建立不同CCT的活体眼模型,分别采用Perkins压平眼压计、A型超声角膜测厚仪、角膜曲率计测量术前、术后Perkins压平眼压、CCT、角膜曲率以及应用电子直接眼压计测量真实眼压,分别对术前和术后测量值做相关分析和多元线性回归分析,并对另1组未行PRK眼测得的真实眼压、Perkins压平眼压、CCT对实验组得出的公式进行验证。结果兔眼双眼Perkins压平眼压、CCT、角膜曲率无统计学差别,无论是术前还是术后Perkins压平眼压与CCT均显著相关(r=0.761P<0.01;r=0.829,P<0.01),与角膜曲率无关(r=0.098,P>0.05;r=0.260P>0.05)。对术前、术后Perkins压平眼压与CCT建立回归公式,曲线的斜率分别为0.066、0.053,Perkins压平眼压的改变与CCT的改变有关。对真实眼压Y与Perkins压平眼压、CCT三者的关系建立回归公式为Y=12.107+1.254X1-0.033X2(X1=Perkins压平眼压,X2=CCT)。结论CCT的改变影响Perkins压平眼压的测量值,临床上应根据CCT来校正Perkins压平眼压的测量值。
Objective To investigate the relationship between central corneal thickness (CCT) and Perkins flattening intraocular pressure (IOP) and to establish a mathematical model of the relationship between CCT, actual IOP and Perkins flattening IOP and the correction formula of CCT on Perkins flattening IOP. Methods Thirty-two New Zealand white rabbits were selected. One of the eyes underwent laser keratorefractive keratectomy (PRK). The data from the other eye was used to validate the data obtained from PRK eyes. A random number table method was used to take one eye randomly. PRK was used to artificially change the CCT of rabbit eyes. A live eye model with different CCTs was established. Perkins tonometer, type A corneal thickness gauge and corneal curvature meter were used respectively Preoperative and postoperative Perkins applanation IOP, CCT, corneal curvature and true intraocular pressure measured by electronic direct tonometer, respectively, preoperative and postoperative measurements were done correlation analysis and multiple linear regression analysis, and the other 1 group The real intraocular pressure (IOP) measured by PRK eye, Perkins (IOP), and CCT were tested by the CCT. Results There was no significant difference of Perkins blood pressure, CCT and corneal curvature in both eyes of the rabbit eyes. Perkins pressure before and after the operation were significantly correlated with CCT (r = 0.761 P <0.01; r = 0.829, P < 0.01), but not with corneal curvature (r = 0.098, P> 0.05; r = 0.260 P> 0.05). Preoperative and postoperative Perkins flattening pressure and CCT regression formula, the slope of the curve were 0.066,0.053, Perkins flattening IOP changes and changes in CCT. For the true intraocular pressure Y and Perkins flattening intraocular pressure, the regression equation of CCT was established as Y = 12.107 + 1.254X1-0.033X2 (X1 = Perkins pressure tonometry, X2 = CCT). Conclusion The changes of CCT affect the measurement of Perkins applanation IOP, and the clinical value of Perkins applanation IOP should be corrected according to CCT.