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目的研究药物性肝病发生的危险因素。方法对2007～2009年收治的确诊的药物性肝病298例患者的服药史、临床表现、肝功能、血清标志及预后进行回顾性分析,并进一步分析其发生的危险因素。结果 298例患者均表现为不同程度的乏力、纳差、黄疸,部分病例有嗜酸细胞增高;不同的药物发生的时间也不同,大多发生在用药后3个月内。性别、年长者、有药物过敏史者和有基础肝病患者是药物性肝病发生的危险因素,但有肝病基础患者的预后和肝功能与无肝病基础的患者无差异。结论性别、年龄、特异性体质、酒精性肝病基础等差异均是药物性肝病的相关危险因素。
Objective To study the risk factors of drug-induced liver disease. Methods The medical history, clinical manifestations, liver function, serum markers and prognosis of 298 patients diagnosed as drug-induced liver disease from 2007 to 2009 were retrospectively analyzed and their risk factors were analyzed. Results 298 patients showed varying degrees of fatigue, anorexia, jaundice, some cases of eosinophilia; different drugs occur at different times, mostly occurred within 3 months after treatment. Sex, the elderly, history of drug allergy, and patients with underlying liver disease are risk factors for drug-induced liver disease, but there is no difference in the prognosis of liver-based patients and liver function as compared with those without liver disease. Conclusion The differences of gender, age, specific constitution and alcoholic liver disease are the related risk factors of drug-induced liver disease.