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To research the relation among the erythrooytic membrane liquidity and the contents of MPA, the activity of SOD in serum of the milk goat with fluorosis. An animal model with fluorosia was constructed, and the fluorescent probe technique of DPH was used to measue the erythrocytic membrane liquidity. At the same time, the contents of MPA and the activity of SOD in serum were measured. The results showed that the erythrocytic membrane liquidity in the control group and flurosis group were 5.6742 ± 0.4417 and 3.7248 ± 0.4521 (P ＜0.01) respectively, the contents of MPA in serum were 2.0408 ± 0.198 and 4.494± 0.438 (P ＜0.01) respectively, the activities of SOD were 175.638 ± 22.201 and 113.714 ± 34.258 (P ＜0.01) respectively. The correlation analysis indicated that the relation between the activity of SOD and the liquidity of erythrocytic membrane was positive correlation ( r=0.7321, P ＜0.05), whereas the relation between the contents of MPA and the liquidity of erythrocytic membrane was negative correlation (r = -0.6438, P ＜0.01). The erythrocytio membrane liquidity decreased in milk goat with fluorosis, which played a role in the occurrence and development of the fluorosis. There was correlation among the erythrocytic membrane liquidity and the contents of MDA, the activity of SOD.